Hi, Eric! hydroxyzine can cause, drowsiness and minor depression. This is from Drugs.com: *Nervous system. Nervous system side effects have included moderate to slight drowsiness. Summary. Depression is found among people who take Hydroxyzine, especially for people who are female, 50-59 old , have been taking the drug for 1 - 6 months, also take medication Prilosec, and have High blood pressure. I can't say for sure that I know what true depression is like, but when I take hydroxyzine, I cannot get out of bed. I can't keep up at work, and I can't motivate myself to do anything. L'hydroxyzine est métabolisée par l'alcool déshydrogénase et les CYP3A4/5 et une augmentation de la concentration sanguine en hydroxyzine peut être attendue lorsque l'hydroxyzine est co-administrée avec des médicaments connus pour être de puissants inhibiteurs de ces enzymes. Hydroxyzine (Vistaril) is an antihistamine drug used to treat allergic reactions, anxiety, tension, nausea, vomiting, and alcohol withdrawal. Common side effects are tiredness, dizziness, sleepiness, and sedation. Drug interactions, dosage, and pregnancy and breastfeeding safety information are provided. Hydroxyzine High: Why Atarax Is So Appealing to Those Seeking. Hydroxyzine, or Atarax, is one of the oldest antihistamine drugs created, and is capable of creating euphoric sensations or a ‘hydroxyzine high’ without becoming addictive. I am not a doctor, so take everything I say with a grain of salt. Here is my Hydroxyzine review and experience. I don't use it much for anxiety, rather as a sleep aid. Bonjour. J'ai pris de l'Atarax. Franchement, c'est assez nul , et, des avis divers glanés sur les forums, je constate que je ne suis pas le seul à le penser. What other drugs will affect hydroxyzine? Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking hydroxyzine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Bonjour Lulubel, Je veux te dire, en premier, que rien ne t'oblige à aller travailler si tu ne t'en sens pas capable. Ce que pense ta psy et ce que toi tu éprouves sont deux choses différentes (si à l'idée de reprendre le travail tu penses que tu vas craquer, il faut lui en parler).